from pysqlcipher import dbapi2 as sqlite3 con = sqlite3.connect("blobs.db") # creating the table con.execute("create table test(id integer primary key, blob_col blob)") con.execute("insert into test(blob_col) values (zeroblob(10))") # opening blob handle blob = con.blob("test", "blob_col", 1, 1) blob.write("a" * 5) blob.write("b" * 5) blob.seek(0) assert blob.read() == "aaaaabbbbb" blob.close()